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YTHDF2 is a key protein that assists in creating healthy blood cells by regulating the bodyā€™s inflammatory response. https://twitter.com/NeuroscienceNew/status/1325907276708896768?s=20 - https://forum.effectivealtruism.org/posts/gtGe8WkeFvqucYLAF/logarithmic-scales-of-pleasure-and-pain-rating-ranking-and #mentalhealth #longevitybrief - ā€œI feel entirely in harmony with myself and the whole world, and this feeling is so strong and so delightful that for a few seconds of such bliss one would gladly give up 10 years of oneā€™s life, if not oneā€™s whole life. [ā€¦] You all, healthy people, canā€™t imagine the happiness which we epileptics feel during the second before our fitā€¦ I donā€™t know if this felicity lasts for seconds, hours or months, but believe me, I would not exchange it for all the joys that life may bring.ā€ā€“ from the character Prince Myshkin in Dostoevskyā€™s novel,Ā The Idiot, which he likely used to give a voice to his own experiences. - On May 26, 2021, at 11:16 AM, Tom Newman thomnewman@gmail.com wrote: - Will check it out - On May 25, 2021, at 10:06 PM, piotr motykiewicz piotr.moty@gmail.com wrote: - https://qualiacomputing.com/2021/05/08/healing-trauma-with-neural-annealing/ - https://youtu.be/T5p9QuqeWsg - #mentalhealth #longevitybrief https://med.stanford.edu/news/all-news/2020/04/stanford-researchers-devise-treatment-that-relieved-depression-i.html https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2019.19070720 - https://twitter.com/agingdoc1/status/1396569848382169089?s=20 Effects of apolipoprotein B on lifespan and risks of major diseases including type 2 diabetes: a mendelian randomisation analysis using outcomes in first-degree relatives #longevitybrief #LPa #apoB ā€œTaken together, our findings show that reductions in apoB should be the primary goal of lipid lowering, because not only does this lead to lower risk of common diseases such as heart disease and stroke, but also a reduction in apoB prolongs life by a period of months to years.ā€ - The importance of apopolipoprotein B (apoB) in major vascular diseases has become increasingly clear. ApoB is the main structural component of atherogenic lipoproteins, and each lipoprotein contains a single molecule of apoB. ApoB therefore represents a direct measure of the total atherogenic particles in the circulation that can enter the arterial wall, and is a more accurate measure of the risk posed by these particles than the mass of cholesterol they contain, estimated by LDL cholesterol or non-HDL cholesterol. - (https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568%2821%2900120-3/fulltext#bib1) - (https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568%2821%2900120-3/fulltext#) - (https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568%2821%2900120-3/fulltext#) - (https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568%2821%2900120-3/fulltext#bib4) - #cancer #longevitybrief https://twitter.com/futurejurvetson/status/1395133351867031552?s=21 Special diets might boost the power of drugs to vanquish cancers. The effects are oftentimes on the same order of magnitude as those from the drugs that we give patients. Thatā€™s a powerful thing to think about." - #longevitybrief #rapamycin https://twitter.com/nathanieledavid/status/1392845724522479627?s=21 Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly1,2. To define the contribution of immune system ageing to organism ageing, here we selectively deletedĀ Ercc1, which encodes a crucial DNA repair protein3,4, in mouse haematopoietic cells to increase the burden of endogenous DNA damage and thereby senescence5,6,7Ā in the immune system only. We show thatĀ Vav-iCre_+/āˆ’_;Ercc1_āˆ’/flĀ mice were healthy into adulthood, then displayed premature onset of immunosenescence characterized by attrition and senescence of specific immune cell populations and impaired immune function, similar to changes that occur during ageing in wild-type mice8,9,10. Notably, non-lymphoid organs also showed increased senescence and damage, which suggests that senescent, aged immune cells can promote systemic ageing. The transplantation of splenocytes fromĀ Vav-iCre+/āˆ’_;Ercc1_āˆ’/flĀ or aged wild-type mice into young mice induced senescenceĀ inĀ trans, whereas the transplantation of young immune cells attenuated senescence. The treatment ofĀ Vav-iCre+/āˆ’_;Ercc1__āˆ’/fl__Ā mice with rapamycin reduced markers of senescence in immune cells and improved immune function11,12. These data demonstrate that an aged, senescent immune system has a causal role in driving systemic ageing and therefore represents a key therapeutic target to extend healthy ageing. - https://twitter.com/agingdoc1/status/1394996116010143746?s=21 #rapamycin #longevitybrief - https://twitter.com/foundmyfitness/status/1394747880280248320?s=21 #coffee #longevitybrief - https://twitter.com/doctor_msc/status/1392844807261888513?s=21 #longevitybrief - https://www.longevity.technology/spermidine-the-mind-enhancing-supplement/ #spermidine #longevitybrief - An aged immune system drives senescence and ageing of solid organs #longevitybrief https://www.nature.com/articles/s41586-021-03547-7 - https://www.technologyreview.com/hub/ai-effect/ #longevitybrief How artificial intelligence is making health care more human - https://twitter.com/ACovarrubiasPhD/status/1392663566335963139?s=20 #longevitybrief Great paper from [@MattYousefzadeh](https://twitter.com/MattYousefzadeh) and Niedernhofer lab showing that senescent immune cells contribute to aging! Congrats to all involved! - https://youtu.be/uuw7BiQEZ-g in this video we look at a paper which looked at using a SIRT1 activator which in turn is shown to up regulate autophagy and suppress cellular senescence. The study used SRT1720 as the SIRT1 activator so we also looked at some of the other studies which had used this molecule #longevitybrief https://twitter.com/davidasinclair/status/1391800942702460932?s=21 https://m.youtube.com/watch?v=uuw7BiQEZ-g&feature=youtu.be SIRT1 suppresses cellular senescence and inflammatory cytokine release in human dermal fibroblasts by promoting the deacetylation of NF-ĪŗB and activating autophagy https://pubmed.ncbi.nlm.nih.gov/33965ā€¦ā€‹ Dr.Ā David Sinclair Twitted https://twitter.com/davidasinclair/stā€¦ā€‹ - https://maiabiotech.com/programs/pipeline/ #longevitybrief #cancer telomerase blocker https://www.youtube.com/watch?v=jIFW_iMRaHU&t=1400s - withings cardiovascular age #longevitybrief https://www.withings.com/kr/en/body-cardio/?utm_source=crm&utm_medium=email&utm_campaign=event_202104_heartmonth_va&utm_content=discover-bc - #spermidine #longevitybrief https://twitter.com/juliab_fitness/status/1391916960234053632?s=21 #Spermidine alleviates vascular calcification by upregulating #SIRT1 and inhibiting ER stress, May 2021 - https://twitter.com/parrishliz/status/1391468162701537282?s=21 #longevitybrief This discussion includes Dr.Ā Williamsā€™ work with gene therapy, cancer research, and follistatin - a myostatin inhibitor. he administered to himself years ago. - https://www.fightaging.org/archives/2021/05/reviewing-the-role-of-gdf11-in-aging/ #gdf11 #longevitybrief #gdf-11 #perry - https://www.longevity.technology/longevity-supplements-report-quicksilver-scientific/ #longevitybrief #supplements #nad - https://twitter.com/foundmyfitness/status/1390352221963907076?s=21 #spermidine Spermidine (found in wheat germ, cauliflower, broccoli, mushrooms, amaranth, aged cheeses, and soybean) improves cognition by boosting mitochondrial function & autophagy. A higher intake of spermidine-rich foods is also linked with better brain function. #longevitybrief #supplements - https://twitter.com/agingdoc1/status/1389348215246499845?s=21 #rapamycin #longevitybrief - Inflammatory Macrophages are Involved in Aortic Aneurysm Formation https://www.fightaging.org/archives/2021/04/inflammatory-macrophages-are-involved-in-aortic-aneurysm-formation/ #longevitybrief - https://twitter.com/foundmyfitness/status/1387831857887080460?s=21 #longevitybrief #supplements A meta-analysis of 17 studies found that people who consumed 18 grams of mushrooms per day had a 45% reduced cancer risk compared to those who did not eat mushrooms.Mushrooms are high in ergothioneine which may blunt oxidative stress in damaged tissues. - https://alivebyscience.com/renue-serum-trial/?_ke=eyJrbF9jb21wYW55X2lkIjogIlJtZE5YWiIsICJrbF9lbWFpbCI6ICJwaW90ci5tb3R5QGdtYWlsLmNvbSJ9 #hairloss #longevitybrief #supplements - While many trials of low-dose Ļ‰3-polyunsaturated fatty acids (Ļ‰3-PUFAs), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) have shown mixed results to reduce cardiovascular events, recent trials with high-dose Ļ‰3-PUFAs have reignited interest in Ļ‰3-PUFAs, particularly EPA, in cardiovascular disease (CVD). REDUCE-IT demonstrated that high-dose EPA (4ā€‰g/day icosapent-ethyl) reduced a composite of clinical events by 25% in statin-treated patients with established CVD or diabetes and other cardiovascular risk factors. ā€œ4ā€‰weeks of 3.4ā€‰g/day omega-3 ethyl esters induced an 8.4-fold increase in plasma %EPA and concurrently increased plasma esterified HEPEs by 5.7-fold, epoxytetraenoic acids (EpETEs) by 4.7-fold and dihydroxyeicostetraenoic acids (DiHETEs) by 4.1-fold.ā€ #longevitybrief #supplements - https://twitter.com/foundmyfitness/status/1386749721830584324 #longevitybrief #omega3 #fishoil #supplements ā€œPeople who supplemented with omega-3 (2.5g/day) then were given a stress test had 19% lower cortisol levels, 33% lower levels of the inflammatory cytokine IL-6, and did not experience a 26% drop in aging biomarkers compared to those given a placebo.ā€ - https://www.[[longevitybrief]].com/posts/rapamycin-in-human-longevity-studies #health [[Article: Meaning of Death ]] - https://www.fightaging.org/archives/2021/04/covid-19-data-shows-the-importance-of-thymic-atrophy-in-aging/ #thymus #[[Audrey de grey ]] Greg Fahy #longevitybrief - blood šŸ©ø test for depression #longevitybrief #mentalhealth https://www.nature.com/articles/s41380-021-01061-w test https://mailchi.mp/c912323bcdb7/future-explored-ev-lithium-metal-batteries-2542251?e=b2755c931e - #herbaltea #mentalhealth #longevitybrief #supplements https://apple.news/A3c7E6v8aSp-MFgvrcWoIJg - https://www.fightaging.org/archives/2021/03/improving-autophagy-to-restore-hematopoietic-function-in-aged-individuals/ Improving Autophagy to Restore Hematopoietic Function in Aged Individuals #longevitybrief #anemia https://news.cuanschutz.edu/news-stories/scientists-discover-ways-of-making-old-blood-new-again #gla - #rapamycin https://www.cfspharmacy.pharmacy/sirolimus-topical-cream https://twitter.com/blagosklonny/status/1373354854761037830?s=21 #longevitybrief - https://www.prenuvo.com/ #longevitybrief #digitalhealth https://www.healthnucleus100plus.com/ #mriscan #humanlongevity - #HbA1c glycation of blood, market of sugar in blood https://www.youtube.com/watch?v=L8bFLDWUs3k&t=523s #longevitybrief - #HbA1c glycation of blood, market of sugar in blood - Melatonin is good to take - https://twitter.com/blagosklonny/status/1369690529764630530?s=21 #rapamycin #longevitybrief - #longevitybrief https://twitter.com/blagosklonny/status/1366821546916986885?s=21 #thenewplan #rapamycin #aspirin - #longevitybrief https://twitter.com/balajis/status/1366066522091712513?s=20 #hairloss - https://twitter.com/mkaeberlein/status/1359524982749995010?s=21 #longevitybrief #rapamycin - Three takeaways from longevity studies in the past 20 years https://peterattiamd.com/RichardMiller/ #peterattia #longevitybrief - from peter: - mTOR matters - less glucose matters - sex specific steroid hormones matter - - Richard Miller - Main surprising takeaway: You can actually put something in food that extends healthy lifespan! - there are actually drugs that work for both male and female, that was surprising - sex specificity for certain drugs - - https://link.springer.com/article/10.1007/s10522-021-09910-5 #rapamycin #longevitybrief - https://twitter.com/blagosklonny/status/1357097399500435456?s=21 #longevitybrief - https://twitter.com/biogerontology/status/1357414461632520192?s=20 #rapamycin #longevitybrief https://twitter.com/ARK_KCL/status/1357120499315339268?s=20 - https://twitter.com/Mangan150/status/1356958552246521858?s=20 #longevitybrief #eggs - https://twitter.com/blagosklonny/status/1356679266667274248?s=21 #longevitybrief #rapamycin - https://twitter.com/brianroemmele/status/1352321050277679104?s=21 #longevitybrief - https://www.fightaging.org/archives/2021/01/klotho-links-inflammation-salt-sensitivity-hypertension-and-mortality-in-aging/ #klotho #longevitybrief - https://twitter.com/blagosklonny/status/1347540855909986305?s=21 #rapamycin #longevitybrief - #longevitybrief https://www.lifespan.io/news/biohackers-perform-first-plasma-dilution-experiment-on-humans/ #plasma - https://twitter.com/blagosklonny/status/1336404328186322947?s=21 #metformin #longevitybrief #cancer - https://www.eurekalert.org/pub_releases/2020-12/wvu-gmr120120.php #longevitybrief #supplements - https://twitter.com/blagosklonny/status/1331465240568094726?s=21 #longevitybrief #cancer - https://twitter.com/foundmyfitness/status/1330271781115076611?s=21

#longevitybrief Hyperbaric oxygen treatment for 3 months was able to reverse some biomarkers of aging in healthy older adults.

The hyperbaric oxygen treatment increased telomere length in blood cells and decreased the number of senescent immune cells. - https://www.nature.com/articles/cddis2014520 #rapamycin It was written 7 years ago. First try. As most of us, I was mistaken about diets (it was not my field at all at that time). Now I think he ate fat meat and no vegetables #longevitybrief - empty space is like unconsciousness, space is like consciousness, when we go to sleep we are the empty space #longevitybrief

worry is a form of hubris worrying is betting against yourself

https://youtu.be/t9S8JNo6JM4

after that you can find your way

sometimes the most transformative truths are the most inconvenient

the truth will liberate you, but first it will make you feel terrible #longevitybrief #gabormate

We further validated the effectiveness of peptide 14 using human skin equivalents and skin biopsies, where peptide 14 promoted skin health and reduced senescent cell markers, as well as the biological age of samples, according to the Skin-Specific DNA methylation clock, MolClock. Topical application of peptide 14 outperformed Retinol treatment, the current gold-standard in ā€œanti-agingā€ skin care. Finally, we determined that peptide 14 is safe for long-term applications and also significantly extends both the lifespan and healthspan of C. elegans worms tested in two independent testings. This highlights the potential for geroprotective applications of the senotherapeutic compounds identified using our screening platform beyond the skin. - https://kathyheist.now.site/home #longevitybrief - trauma is internal wound trauma is disconnection from self disconnection from other people disconnection from nature

https://youtu.be/tef5_HK5Zlc #longevitybrief - https://twitter.com/blagosklonny/status/1324399697503674369?s=21

#rapamycin #longevitybrief - every feeling that I have is chosen by me based on my body identification. It can happen only to identity that I made up, and it cannot happen to who I am in truth, it never did happen to who I am in truth, but it did happen to who I thought I was, and Iā€™m not who I think I am.

-1. itā€™s impossible for me to be hurt by an other (emotionally) 0. I can only be hurt by myself 1. itā€™s my thoughts alone that cause me pain 2. when thinking about past trauma think of that 3 years old. not yourself receiving it when being critized donā€™t think of it as you but your old self when being snuffed and ignored donā€™t think of it as you but your baby self

https://youtu.be/kBszXuRp7WE #mentalhealth #longevitybrief - Donā€™t avoid people who trigger you, run to them to experience the pain and heal more

any trigger is opportunity for healing

ā€œmy mother was 5 minutes latesā€ how feelings about not being lovable are made, are huge for child

when in pain, ask your self ā€œwhoā€™s the I thatā€™s in pain?ā€ whoā€™s the I that has the headache itā€™s the body identification thatā€™s causing the pain whoā€™s the I thatā€™s having the experience

you have to be aware of the sabotage that your ego is trying to do, always ask ā€œwhoā€™s the I that just said thatā€, and the answer is no thatā€™s not who I am I have to learn to listen to the true self the true self will not speak unless I ask I have to learn to ask listen to the voice that of the loving self accept that truth

https://youtu.be/kBszXuRp7WE #longevitybrief #mentalhealth - https://www.news-medical.net/news/20201103/Novel-molecules-show-potential-for-future-cancer-therapies.aspx #longevitybrief #cancer - Resting Metabolic Rate In an analysis of data from the Baltimore Longitudinal Study of Aging (BLSA), subjects in good health and functional status had lower RMR than those affected by chronic diseases and functional limitations, independent of age, sex and body composition. Also, independent of relevant confounders, higher RMR was cross-sectionally associated with both a higher number of chronic diseases and with significantly higher risk of developing multimorbidity, defined as two or more out of 15 chronic conditions. #longevitybrief https://www.fightaging.org/archives/2020/10/resting-metabolic-rate-in-aging-and-age-related-disease/ - Proteomic Analysis of Blood Samples Points to the Importance of Inflammation in Aging https://www.fightaging.org/archives/2020/10/proteomic-analysis-of-blood-samples-points-to-the-importance-of-inflammation-in-aging/ #biomarkers #longevitybrief - https://www.fightaging.org/archives/2020/10/another-new-senolytic-prodrug-is-demonstrated-to-reverse-frailty-and-loss-of-cognitive-function-in-old-mice/ #senolytic #longevitybrief - https://twitter.com/scobleizer/status/1322976492754595840?s=21 #longevitybrief #biomarkers - https://twitter.com/blagosklonny/status/1323052085361942530?s=21 #longevitybrief antagonistic pleiotropy Life-limiting diseases in worm are development driven, not caused by molecular damage: A new study has found that, in the nematode worm Caenorhabditis elegans, biomass conversion from the intestine to yolk, mediated by autophagy and insulin/IGF-1 signaling, promotes reproduction in early life but aging in late life. - https://twitter.com/paulojsvaz/status/1323064477424717825?s=21

#longevitybrief #supplements spermidine rapamycin rapalog - https://youtu.be/LtHlw7QJT7Y nutritional psychologist psychiatrist #longevitybrief - food - mood connection - gluten associated with anxiety sweets associated with anxiety - turmeric, cucumerin, black pepper, sofrito, are good glutamates bad for OCD

- eating trans fats associated with depression

#longevitybrief #cancer

Gene Therapy and Your Heart Does salt spike your blood pressure?

Is your cholesterol high despite your best efforts?

Does it not seem to matter what you do?

These are all worrying and frustrating. We do our best to help our health, but sometimes we canā€™t get those numbers to budge. Some of us are dealt bad hands, but time is working against all of usā€¦

Worse yet, our genes just go with the flow. They do a fantastic job of keeping us healthy for the first three decades of our lives, but start to slack off as we approach middle age.

Weā€™ve outlined how, by keeping muscle mass on and fat off, follistatin might be the single best preventative measure against heart disease on the market. Klotho and telomerase also have potentially wide-ranging benefits for your cardiovascular health.

Getting to the Bottom of Things Salt intake affects blood pressure, but more so for some than others. The exact reasons are being revealed. One of them is Klotho.

Itā€™s been known for years that declining levels of Klotho accelerate artery stiffening. A new study found that it also affects salt sensitivity and is now a promising candidate for preventing hypertension in the elderly.

Shorter telomeres are implicated in all-cause mortality. In other words, shorter telomeres increase your chances of dying from virtually all ā€œnaturalā€ causes. Short telomeres, by encouraging inflammation and reducing stem cell proliferation (among other things), contribute to atherosclerosis.

Plaque buildup can also be traced to dysfunctional metabolism. A healthy metabolism depends on a healthy amount of lean body mass and adipose (fat) tissue. This is where follistatin comes into the picture. Skeletal muscle is key to staying mobile, staying fit, and keeping Metabolic Syndrome - insulin insensitivity, high cholesterol, high blood pressure, etc. - at bay.

All three of these gene therapies show incredible promise in delaying, preventing, and perhaps even reversing cardiovascular disease.

Follistatin Gene Therapy Follistatin gene therapy has been used with success in patients with Duchenne and Beckerā€™s muscular dystrophy safely and effectively.

In healthy subjects given epicatechin (a compound that elevates follistatin levels) markedly increased their grip strength. Although this seems crude, grip strength is a good biomarker of general health and predictor of all-cause mortality. They saw this happen within one week.

It seems not just likely, but inevitable, that gene therapies like telomerase, follistatin, and Klotho will be used as means to prevent or alleviate Type 2 diabetes. Want to learn more?

Please visit Integrated Health Systems.

References and Suggested Reading Aviv, Abraham, Jeremy D. Kark, and Ezra Susser. ā€œTelomeres, atherosclerosis, and human longevity: a causal hypothesis.ā€ Epidemiology (Cambridge, Mass.) 26.3 (2015): 295.

Cawthon, Richard M., et al.Ā ā€œAssociation between telomere length in blood and mortality in people aged 60 years or older.ā€ The Lancet 361.9355 (2003): 393-395.

Gao, Diansa, et al.Ā ā€œActivation of SIRT1 Attenuates Klotho Deficiencyā€“Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity.ā€ Hypertension 68.5 (2016): 1191-1199.

Kawarazaki, W., et al.Ā (2020) Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency. Journal of Clinical Investigation. doi.org/10.1172/JCI134431.

Wang, Qi, et al.Ā ā€œTelomere length and all-cause mortality: a meta-analysis.ā€ Ageing research reviews 48 (2018): 11-20. - https://www.longevity.technology/oneskin-launches-topical-senetherapeutic-skin-treatment/ #longevitybrief skincare - https://www.longevity.technology/move-over-cartography-this-is-heartography/ #longevitybrief - https://www.longevity.technology/time-to-haul-sasp-back-to-the-beginning/ #longevitybrief sasp senescent senescence - https://twitter.com/aginghighlights/status/1318528417923538945?s=21 The biological bases of longevity are not well understood, and there are limited biomarkers for the prediction of long life. We used a highā€throughput, discoveryā€based proteomics approach to identify serum peptides and proteins that were associated with the attainment of longevity in a longitudinal study of communityā€dwelling men age ā‰„65 years. #longevitybrief #biomarkers Complement component C9 āˆ’1.217 0.0002 S100A9 S10A9 3 Protein S100ā€A9 āˆ’1.206 0.0700 CD163 C163A 5 Scavenger receptor cysteineā€rich type 1 protein M130 āˆ’1.179 0.0179 CRP CRP 6 Cā€reactive protein āˆ’1.170 0.0183 IGHM IGHM 19 Immunoglobulin heavy constant mu āˆ’1.157 0.0002 C7 CO7 49 Complement component C7 āˆ’1.150 0.0001 FCGR3A FCG3A 4 Low affinity immunoglobulin gamma Fc region receptor IIIā€A āˆ’1.148 0.0984 LGALS3BP LG3BP 14 Galectinā€3ā€binding protein āˆ’1.148 0.0002 NRP1 NRP1 3 Neuropilinā€1 āˆ’1.140 0.0966 ALCAM CD166 4 CD166 antigen āˆ’1.139 0.0535 GPLD1 PHLD 7 Phosphatidylinositolā€glycanā€specific phospholipase D āˆ’1.136 0.0239 B2 M B2MG 7 Betaā€2ā€microglobulin āˆ’1.133 0.0133 A2 M A2MG 21 Alphaā€2ā€macroglobulin āˆ’1.133 0.0002 MMP2 MMP2 5 72 kDa type IV collagenase āˆ’1.132 0.0286 VWF VWF 58 von Willebrand factor āˆ’1.120 0.0001 CSF1R CSF1R 5 Macrophage colonyā€stimulating factor 1 receptor āˆ’1.119 0.0390 HPR HPTR 13 Haptoglobinā€related protein āˆ’1.117 0.0003 CFD CFAD 7 Complement factor D āˆ’1.111 0.0078 CD5L CD5L 6 CD5 antigenā€like āˆ’1.111 0.0788 FCGBP FCGBP 34 IgGFcā€binding protein āˆ’1.108 0.0001 IGHG3 IGHG3 13 Immunoglobulin heavy constant gamma 3 āˆ’1.106 0.0014 F2 THRB 53 Prothrombin āˆ’1.104 0.0001 CST3 CYTC 7 Cystatinā€C āˆ’1.102 0.0569 PTGDS PTGDS 4 Prostaglandinā€H2 Dā€isomerase āˆ’1.101 0.0826 MCAM MUC18 7 Cell surface glycoprotein MUC18 - https://twitter.com/aginghighlights/status/1318803981267853318?s=21 #longevitybrief senolytic senescence - https://www.barrons.com/articles/crispr-therapeutics-gene-edited-treatment-stopped-cancer-in-some-patients-51603288926 #cancer #longevitybrief #crispr - https://medicalxpress.com/news/2020-10-epigenomic-platform-early-stage-pancreatic-cancer.html #cancer #longevitybrief Bluestar Genomics has published study results in the peer-reviewed journal Nature Communications demonstrating the power of the companyā€™s platform to detect pancreatic cancer in its early stages, addressing the unmet need of more than 60,000 patients diagnosed with the disease each year in the United States alone. The epigenomic platform analyzes a simple blood draw and identifies the presence of pancreatic cancer in patientsā€™ DNA circulating in their blood, enabling non-invasive, precise detection of the disease, which could lead to more timely treatment and improved patient survival. #biomarkers Bluestar Genomics has published study results in the peer-reviewed journal Nature Communications demonstrating the power of the companyā€™s platform to detect pancreatic cancer in its early stages, addressing the unmet need of more than 60,000 patients diagnosed with the disease each year in the United States alone. The epigenomic platform analyzes a simple blood draw and identifies the presence of pancreatic cancer in patientsā€™ DNA circulating in their blood, enabling non-invasive, precise detection of the disease, which could lead to more timely treatment and improved patient survival. - https://twitter.com/blagosklonny/status/1317971347985866755?s=21 #rapamycin #longevitybrief - A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19 thelancet.com/journals/ebiomā€¦ #COVID19 #coronavirus #digitalhealth IL-6 IL-10 https://twitter.com/johnnosta/status/1318246565107109888?s=21 #longevitybrief #biomarkers - https://www.technologynetworks.com/genomics/news/breakthrough-blood-test-developed-for-brain-tumors-341630 #cancer #longevitybrief - https://www.longevity.technology/shca-proteins-new-targets-for-age-related-diseases/ #longevitybrief - https://www.longevity.technology/deliver-us-from-aging-the-quicksilver-method/ package #supplements in liposome delivery system for better bio-available #longevitybrief - https://pubs.acs.org/doi/full/10.1021/acschembio.0c00093 SENS Generation and Characterization of Anti-Glucosepane Antibodies Enabling Direct Detection of Glucosepane in Retinal Tissue. Glucosepane is a critical form of cross-linking damage, associated with multiple age-related health problems, including diabetes, arteriosclerosis, retinopathy, and joint stiffening. #longevitybrief - https://www.fightaging.org/archives/2020/10/klotho-in-aging-and-the-failing-kidney/ #klotho #longevitybrief - https://twitter.com/foundmyfitness/status/1315402532340916224?s=21 #cancer #longevitybrief - https://futurism.com/neoscope/injection-gene-edit-specific-parts-brain #longevitybrief - https://www.longevity.technology/new-spermidine-lifespan-supplement-launches/ #supplements #longevitybrief - https://www.integrated-health-systems.com/register/ #longevitybrief #klotho #telomeres - https://www.technologynetworks.com/tn/news/biochip-innovation-combines-ai-and-nanoparticles-to-analyze-tumors-341387 #biomarkers #cancer #longevitybrief - https://www.reddit.com/r/singularity/comments/j7mt55/genetic_factor_discovery_enables_adult_skin_to/?utm_source=share&utm_medium=ios_app&utm_name=iossmf #longevitybrief - World-renowned lipidologist Tom Dayspring returns to give an update on the current thinking in lipidology as a follow-up to his 2018 five-part podcast series. In this episode, Tom discusses the growing consensus that atherogenic lipoproteins are essential drivers of atherosclerotic vascular disease. Tom further emphasizes apolipoprotein B (apoB) and lipoprotein(a) (Lp(a)). He provides insights into risk assessment, including which lab metrics to use, how to interpret them, and the appropriate therapeutic targets. Additionally, Tom discusses the most recent developments in lipid-lowering drug therapiesā€”from the continued evolution of PCSK9 inhibitors, to the latest understanding of EPA and DHA, and the most recent addition of bempedoic acid to the list of therapeutic agents. #LPa #longevitybrief #supplements - https://www.longevity.technology/psychobiome-trusting-your-gut-for-longevity/ #biomarkers #gut #psychobiome #longevitybrief - https://bioengineer.org/high-blood-pressure-and-salt-anti-aging-factor-klotho-key/ #longevitybrief #klotho #parrish - https://www.wired.com/story/a-common-plant-virus-is-an-unlikely-ally-in-the-war-on-cancer/ #longevitybrief #cancer - https://www.lifeextension.com/newsletter/2020/10/research-shows-promise-for-gum-disease?sourcecode=HEXX171E&utm_source=newsletter-ezine&utm_medium=email&utm_campaign=HEXX171E&utm_content=image-hero&utm_term=&M_BT=4379292010051 #longevitybrief #supplements - https://twitter.com/charlesmbrenner/status/1313557517356593152?s=21 #nr #nad #supplements #longevitybrief #covid - https://www.longevity.technology/nutraceuticals-to-mitigate-immunosenescence-and-aging/ #longevitybrief #supplements - https://twitter.com/blagosklonny/status/1313672612246061056?s=21 #cortisol #supplements #longevitybrief - 1. start collecting data (yesterday) 2. look in the directions of energy and emotions how they are controlled by our biological markers (nutrients, hormones, neurotransmitter, iron, anemia), establish what controls your energy, and increase it 3. reinvest this increase in energy into bio-hacking Stanislav Skakun #biohacking #longevitybrief reasons why itā€™s difficult to build business in this space: health is type 2 decision (not immediate concern) so immediate total addressable market is small humans did not evolve to think / plan in decades, most of our planing revolves around today/tomorrow - #longevitybrief articles: - my journey, log of things Iā€™ve done and looking to do - immune boosting based on day 1 of RAADfest 2020 - stem cell therapies - - https://twitter.com/orlando_uy/status/1306907285806030852?s=21 #rapamycin #longevitybrief - https://twitter.com/blagosklonny/status/1306362093860524037?s=21 #rapamycin #longevitybrief - https://www.sciencealert.com/a-new-cancer-treatment-uses-a-trojan-horse-approach-and-no-drugs #cancer #longevitybrief - Naringenin is a Senotherapeutic that Enhances Neurogenesis in Mice https://www.fightaging.org/archives/2020/09/naringenin-is-a-senotherapeutic-that-enhances-neurogenesis-in-mice/ #longevitybrief - https://medicalxpress.com/news/2020-09-artificial-intelligence-osteoarthritis-years.html #machinelearning #longevitybrief - https://medicalxpress.com/news/2020-09-link-brains-d-implants.html #neurallink #longevitybrief - https://twitter.com/blagosklonny/status/1302385817592238084?s=21 #rapamycin #longevitybrief - https://3dprint.com/272414/3d-printed-drug-delivery-implant-achieves-successful-clinical-trial-for-parkinsons-disease/ #longevitybrief - https://en.wikipedia.org/wiki/Fisetin #longevitybrief flavonoid senolytic tested in mice, improves longevity, helps in fighting covid, tested mouse on related corona virus (fisetin it reduced cytokine storm, also helps with immune response) by Laura Jane Niedernhofer from University of Minnesota - https://twitter.com/blagosklonny/status/1298965189988175872?s=21 #longevitybrief - https://twitter.com/blagosklonny/status/1297880274286649345?s=21 #rapamycin #longevitybrief - https://www.fightaging.org/archives/2020/08/trem2-inhibition-as-a-potentially-broadly-effective-cancer-therapy/ #longevitybrief - https://twitter.com/blagosklonny/status/1271408103960064000?s=21 #longevitybrief - https://twitter.com/blagosklonny/status/1295048493757800448?s=21 #longevitybrief #supplements #rapamycin - https://www.fightaging.org/archives/2020/08/gdf15-helps-to-resist-age-related-chronic-inflammation/ gdf15 #longevitybrief - https://link.medium.com/L3ik3AY5E8 What Could Blockchain Do for Healthcare? #longevitybrief [[ideas]] - https://twitter.com/artirkel/status/1290051837278609409?s=21 #longevitybrief - https://www.fightaging.org/archives/2020/07/a-genomic-search-for-longevity-associated-genes-points-to-iron-metabolism-in-human-aging/ #longevitybrief - https://twitter.com/blagosklonny/status/1289288861151973376?s=21 #longevitybrief - https://www.nature.com/articles/s42255-020-0247-0 #longevitybrief - https://www.reddit.com/r/longevity/comments/hy5yl0/growth_differentiation_factor_15_protects_against/?utm_source=share&utm_medium=ios_app&utm_name=iossmf #longevitybrief - https://www.reddit.com/r/longevity/comments/hy64vi/calorie_restriction_increases_the_number_of/?utm_source=share&utm_medium=ios_app&utm_name=iossmf #longevitybrief - https://twitter.com/mangan150/status/1286793786631188480?s=21 #longevitybrief - https://nintil.com/longevity #longevitybrief - https://twitter.com/blagosklonny/status/1283922390536331266?s=21 #longevitybrief - https://twitter.com/blagosklonny/status/1283195784054427648?s=21

#longevitybrief - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/ Rapamycin for longevity: opinion article #supplements #longevitybrief - https://www.fightaging.org/archives/2020/07/calcium-alpha-ketoglutarate-supplementation-reduces-epigenetic-age-in-humans/ #longevitybrief #supplements AKG Ponce de Leon Health initially worked with Dr.Ā Brian Kennedy, who was, at the time, based at the Buck Institute for Research on Aging, searching for compounds that were generally recognized as safe (GRAS) but that had the potential to influence aging in mammals. The company screened over 300 GRAS compounds and identified compounds that could modulate a number of pathways that are linked to aging. Dr.Ā Kennedy subsequently joined Ponce de Leon Health as its Chief Scientific Officer, and the company has been busy testing and preparing to translate these findings to people. Its strategy has been to test its products on mammalian models that closely emulate human aging in order to give the best chance of translating beneficial results to us.

For consumer testing the company gave participants Rejuvant and measured their epigenetic ages using DNA methylation testing. This supplement contains a proprietary form of calcium alpha-ketoglutarate, which the FDA considers to be GRAS. The company believes that Rejuvant works by slowing down the rate of age-related DNA methylation and reducing the inflammation caused by senescent cells, two proposed reasons why we age. - https://www.reddit.com/r/longevity/comments/hm5jkr/liz_parrish_master_of_your_immune_system_the/?utm_source=share&utm_medium=ios_app&utm_name=iossmf #longevitybrief - https://www.reddit.com/r/longevity/comments/hhr4ga/a_cure_for_heart_disease_a_single_shot_succeeds/?utm_source=share&utm_medium=ios_app&utm_name=iossmf #longevitybrief - https://www.diamandis.com/blog/regenerative-medicine?utm_campaign=Tech%20Blog&utm_medium=email&_hsmi=90374066&_hsenc=p2ANqtz-_cfyDqCoVrCzmEhIV2s-XvHZUAD_lAmTRvMroj1zXEFfgiXeA8xFcxYkMd-9sONYXiuGNCG04Ls2SYjJt9lOLZIj5kUg&utm_content=90374066&utm_source=hs_email

In a Stanford study, seven of 18 stroke victims who agreed to stem cell treatments showed remarkable motor function improvements.

This treatment could work for other neurodegenerative conditions such as Alzheimerā€™s, Parkinsonā€™s and ALS.

#longevitybrief #[[longevity companies]] - https://www.youtube.com/watch?v=1XsURnec1m8&t=698s #longevitybrief viome naveen jain #supplements - some couples that have lived together for long time have very similar gut biome - custom tailored [[supplements]] for individual - ^ā€œprecision [[supplements]]ā€^ - metformin modifies gut biome - statin drugs modify gut biome - ā€œnaturalā€ is bad label - ā€œto preserve freshnessā€ is bad label - https://www.youtube.com/watch?v=dRvnJOPjDDo #longevitybrief naveen jain viome : microbiome + mitochondrial + human gene expression rethink food: what if we can crispr our genes to take energy via photosynthesis or from radiation (there are bacteria that can live off of radation) mouth biodiversity is also important, more diversity than in gut, leaky gum disease efficacy of drugs is dependent on microbiome gut, mouth, sinuses, brain, blood, skin microbiomes microbiome could be the ā€˜soulā€™, could have ā€˜conciousnessā€™ if your microbiome is suicidal / doesnā€™t want to live you donā€™t want to live, if your microbiome wants to live you will live 99% of genes in your body are not your dna (99% is your biome and mitochondrial genes) - - https://www.bbc.com/news/health-53137328 #longevitybrief - consciousness constructs time, reality, controls processes in our body [[book: Metahuman]] #longevitybrief - to exist is to think and vice versa to think is to exist [[book: Metahuman]] #longevitybrief - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128428/ spermidine #longevitybrief ā€œExternal supply of the natural polyamine spermidine can extend life span in model organisms including yeast, nematodes, flies and mice. Recent epidemiological evidence suggests that increased uptake of spermidine with food also reduces overall, cardiovascular and cancer-related mortality in humans. Here, we discuss the possible mechanisms of this intriguing spermidine effect.ā€ Good dietary sources of spermidine are aged cheese, mushrooms, soy products, legumes, corn, and whole grains.[14]Ā Spermidine is plentiful in aĀ Mediterranean diet.[3]Ā For comparison: The spermidine content in human seminal plasma varies between approx. 15 and 50 mg/L (mean 31 mg/L).[15] - https://twitter.com/foundmyfitness/status/1273713302443442176?s=20 #longevitybrief - Dave Asprey and molly maloof https://blog.daveasprey.com/molly-maloof-706/ #longevitybrief #supplements #microbiome - Mitochondria - continuous glucose monitor CGM and HVR heart variablity rate tell him how his body is doing - our genetics are designed for fasting - too much food is aging us - Molly is monitoring with CGM and ketones during fast (and additionally cortisol would be great). During fasting if ketones are going up and glucose is going down thatā€™s good, if the glucose is staying up thatā€™s bad. Itā€™s a test how well metabolically you can tap into fat reserves. Some athletes cannot tap into ketones and they crash. - Viome, Inc.Ā they can tell you what your blood sugar will be after eating certain food based on the composition of your gut biome https://www.viome.com - two ways of damaging your mitochondria: 1. eating too much 2. not using up the fuel that you have: the benefit of exercise is using your fuel, thatā€™s a way to become metabolically flexible, fasting exercise is best for this, exercise while fasting - 19 daggers of heart disease #supplements #longevitybrief #plantbaseddiet - https://www.lifeextension.com/magazine/2018/2/as-we-see-it - skin aging https://www.fightaging.org/archives/2020/06/stem-cell-therapy-reverses-aspects-of-photoaging-in-skin/ #longevitybrief - glucose cgm #biomarkers #longevitybrief https://www.abbott.com/life-changing-tech/revolutionizing-cgm-with-freestyle-libre.html - https://www.reddit.com/r/longevity/comments/gyrht2/a_compound_sch79797_that_can_simultaneously/?utm_source=share&utm_medium=ios_app&utm_name=iossmf ā€œ It does make you wonder will society become very dull - definitely no skydiving, but maybe even worried about even going outside. Which is what the rich in Surrogates (Bruce Willis) ended up doing - sending out their humanoid replicants instead.ā€ ā€œ Yeah I think if we cure ageing, then people will realise that there is no time limit on their lives, so theyā€™d probably start being really careful to not die because theyā€™d be giving up hundreds/thousands of years rather than decades. So I think safety would become paramount in all parts of society.ā€ [[Article: science of aging]] [[Article: Meaning of Death ]] [[longevitybrief]] - https://www.youtube.com/watch?v=yrCaG2gT2Vg #plantbaseddiet #longevitybrief - LPa biomarker (also called sticky cholesterol), very important to check, (lipoprotein a) 27% have elevated levels, statins donā€™t lower it, niacin (b-vitamin) shows to lower it [57:40] - test ā€œare my heart arteries calcifiedā€ calcification test (cat scan of the heart), CACS test (coronary artery calcium scan) very important, calcium score (bad: 1400 - 1100, 0 is best), calcium score is a sign of aging, cost $70 [60:00] - interesting fact, endurance athletes can have increased calcification - {{[[TODO]]}} watch Widow Maker on Netflix - - https://www.reddit.com/r/longevity/comments/gwe55j/carolina_oliveira_ceo_oneskin_showcasing_the/?utm_source=share&utm_medium=ios_app&utm_name=iossmf #longevitybrief #[[longevity companies]] - White adipose tissue (WAT) is considered the bodyā€™s energy storage for times of energy scarcity while brown adipose tissue (BAT) is a unique, major energy consuming, heat producing organ. #longevitybrief - https://twitter.com/blagosklonny/status/1268565613452177408?s=21

#longevitybrief - stem cell treatment for baldness https://interestingengineering.com/baldness-cure-possible-with-stem-cell-topical-solution ADSC-CE https://www.fightaging.org/archives/2020/05/secreted-stem-cell-factors-as-a-treatment-for-male-pattern-baldness/ #longevitybrief - https://www.reddit.com/r/longevity/comments/gv1ih5/reason_ceo_of_repair_biotechnologies_showcasing/?utm_source=share&utm_medium=ios_app&utm_name=iossmf removing oxidized cholesterol #supplements #longevitybrief - Your Thymus is Disappearing: https://mailchi.mp/375989789d83/your-thymus-is-disappearing bioviva #longevitybrief - https://www.reddit.com/r/longevity/comments/gsrsd1/avoid_the_use_of_dq_as_a_senolytic_therapy/?utm_source=share&utm_medium=ios_app&utm_name=iossmf #longevitybrief - https://www.reddit.com/r/longevity/comments/gt0bxl/the_quest_to_slow_ageing_through_drug_discovery/?utm_source=share&utm_medium=ios_app&utm_name=iossmf #longevitybrief - https://www.longevity.technology/building-an-artificial-immune-system/ #longevitybrief - https://www.youtube.com/watch?v=g-o_G41IZJs #longevitybrief #biomarkers - https://www.webmd.com/vitamins/ai/ingredientmono-144/alpha-ketoglutarate-akg safe up to 3g grams [22:00] first trial starting #supplements - https://www.rejuvant.com/ rejuvant product by Ponce De Leon Health Ponce De Leon Health product https://www.rejuvant.com/FAQS [[Article: science of aging]] twitter social media for companies: nanotics, haut.ai, NetraMark, https://www.repairbiotechnologies.com/, lygenesis, https://www.gerostatealpha.com/, https://lvf.vc/contact, ponce de leon health (rejuvente product), https://gdf11rejuvenation.com/contact-us, https://age-reversal.net/, longevity.school (3 stages), https://nadmd.com/aging-reversal/, https://www.klick.com/ [[longevity companies]] - akg possibly affects dna methylation, lowering it so should be reflected in Horvathā€™s clock
- bats developed strategy in their immune system to tolerate sars viruses to not have overt response of immune system, that leads them to be able to live longer, they are more resistant to increased inflammation that occurs with aging, they may be resistant to deleterious effects of senescent cells in their bodies, - torcept company, main focus to improve upon rapamycin (develop rapalogs), to inhibit mTorc1 complex and inhibit less of mTorc2 (where the side effects come from). For cancer drug companies are developing drugs that inhibit both mTorc1 and mTorc2. Some research is showing that for anti aging itā€™s best to inhibit mTorc1 but activate mTorc2 - {{[[TODO]]}} research Brent Nally youtube channel on his Mesenchymal stem cells therapy - in mole rats they found Hyaluronic acid effect on their longevity, they tried in mouse with promising results #supplements https://g.co/kgs/CUoybZ - dr ed park, recharge biomedical, injecting patients with https://kimeralabs.com/exosomes/ exosomes http://www.rechargebiomedical.com/about-dr-park/ telomeres - {{[[TODO]]}} go to RAADFest - https://www.youtube.com/watch?v=avoHaUbECLQ interview with Liz Parrish - took telomerase growth and Follistatin myostatin inhibitor (gdf-8) for two years , triglycerides went down, blood sugar level went down - https://www.prnewswire.com/news-releases/direct-biologics-llc-announces-the-launch-of-exoflo-exosomes-300881151.html exosomes hair regrowth exosomes #hairloss https://directbiologics.com/growth-factors/ - in studies on animals, in isocaloric experiments (same calories), ā€œhigh carb, low proteinā€ generates the longest lifespan, in humans weā€™re just getting too many calories. Fasting is largely safe. #supplements - l-nutra diet https://l-nutra.com/ fasting mimicking diet, good for healthy people, but for older people, you suffer from under šŸ„œ nutrition #supplements - https://www.lifevantage.com/us-en/blog/shake-off-the-rust-the-oxidative-stress-theory-of-aging oxidative stress #longevitybrief #supplements - personalized medicine: measure first then supplement what youā€™re missing - dr. Bill Andrews is big proponent of telomeres - https://www.youtube.com/watch?v=BCcujAcbi-8#action=share insilico #longevitybrief - PGC-1Ī± (PGC-1 alpha) is the master regulator of mitochondrial biogenesis. In other words, itā€™s in charge of making new mitochondria. As the powerhouses of cells, mitochondria are needed to maintain a healthy body weight, optimal energy levels, and normal brain function. #biomarkers #longevitybrief https://www.youtube.com/watch?v=UQH8RzsxadY - https://twitter.com/blagosklonny/status/1265290681792311302?s=21
rapamycin #longevitybrief torcept company, main focus to improve upon rapamycin (develop rapalogs), to inhibit mTorc1 complex and inhibit less of mTorc2 (where the side effects come from). For cancer drug companies are developing drugs that inhibit both mTorc1 and mTorc2. Some research is showing that for anti aging itā€™s best to inhibit mTorc1 but activate mTorc2 - https://alivebynature.com/product/lsg-fisetin-liposomal-sublingual-gel/ fisetin senolytic #longevitybrief - https://www.inverse.com/innovation/microscopic-robots-could-take-your-body-on-a-fantastic-voyage Itā€™s straight out of science fiction: robots entering your body to heal injuries. But scientists at the Max Planck Institute are making it a reality.

They have successfully tested artificial white blood cells in an artificial bloodstream, proving that they can withstand the rigors of the body.

Inspired by a historic nanotech challenge, these quick and rugged bots can be the calvary for a body struggling with illness. These tiny robots that could soon be taking a fantastic voyage through your body ā†’ #longevitybrief [[Article: science of aging]] [[Article: dematerialization]] - {{[[mentions]]: [[longevitybrief]]}}