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Piotr M.

Human Longevity

Latest on human longevity studies

Here's TL;DR for those curious about the Human Longevity studies who also don't have the patience or the luxury to spend hours/days on end sifting through all the ever-advancing science. Some basics to start with:

  1. There appears to be food / supplements you can take (or remove harmful ones, depending on how you look at it) in your diet that will extend healthy life-span (add years to your life). This was a controversial idea not too long ago.
  2. No, there are no moral issues to working on extending human life-span. Earth is mostly empty actually. We need more people not less (if we stand a chance to solve the challenges we are facing - yes, some of them created by us, but what would one rather have, no challenges at all and therefore no humans that created them, or human existence that comes with problems to solve?)
  3. Degrowth'ers are wrong, just as Malthusians were in the 1800s and 1900s.

More tidbits for those willing to explore further:

  • Limiting sugar intake (simple carbs) appears to have beneficial effects
  • Moderate exercise appears to have beneficial effects
  • mTOR pathway matters (selectively down-regulating it via rapalogs appears to extend lifespan)
  • sex specificity for certain drugs
  • Inflammaging, as we age our bodies experience increasing levels of persistent low-grade inflammation, which has cascading effects, degrading our health
  • Preserving the length of telomeres appears to have beneficial effects
  • Controlling proliferation of senescent cells appears to have beneficial effects
  • Diluting pro-aging factors in blood (plasma dilution) appears to have beneficial effects
  • Conversely, supplementation (injection) with youth factors in blood (those that decrease with age) appears to have beneficial effects, this includes GDF11, various other hormones, etc. Counteracting Thymus involution with hormones as well.
  • Plethora of dietary supplements and generic drugs that appear to have off-target pro longevity effects, though still in need of long term study results, and with unknown side effects especially when combining one or more of these together: Rapamycin, Metformin, NMN, Resveratrol, Calcium AKG, Quercetin, Fisetin, Spermidine, etc. etc.
  • Many more to list here in this brief introductory compilation

Some of these interventions are free / very low cost. Some of these are still very expensive / exotic, and worth noting not backed by comprehensive FDA vetted clinical trials. It will take time to validate safety / efficacy but we are on a path to getting there, as well as lowering the costs for everyone to administer, if they choose to do so.

CAUTION -- none of the information found here should be taken as medical advice! But we are at a point where by first, actively monitoring various aspects of your health and then selectively applying some of these interventions those actions will likely have a positive outcome on your healthy aging (and as consequence will potentially extend your healthy life-span as well).

Further reading:

  • My ever-growing cliff notes on Longevity research
  • My Longevity blog: www.longevitybrief.com